Dataset Information

Characteristics and outcomes of hospitalised adults with COVID-19 in a Global Health Research Network: a cohort study.

ABSTRACT:

Objective

To examine age, gender, and temporal differences in baseline characteristics and clinical outcomes of adult patients hospitalised with COVID-19.

Design

A cohort study using deidentified electronic medical records from a Global Research Network.

Setting/participants

67 456 adult patients hospitalised with COVID-19 from the USA; 7306 from Europe, Latin America and Asia-Pacific between February 2020 and January 2021.

Results

In the US cohort, compared with patients 18-34 years old, patients ≥65 had a greater risk of intensive care unit (ICU) admission (adjusted HR (aHR) 1.73, 95% CI 1.58 to 1.90), acute respiratory distress syndrome(ARDS)/respiratory failure (aHR 1.86, 95% CI 1.76 to 1.96), invasive mechanical ventilation (IMV, aHR 1.93, 95% CI, 1.73 to 2.15), and all-cause mortality (aHR 5.6, 95% CI 4.36 to 7.18). Men appeared to be at a greater risk for ICU admission (aHR 1.34, 95% CI 1.29 to 1.39), ARDS/respiratory failure (aHR 1.24, 95% CI1.21 to 1.27), IMV (aHR 1.38, 95% CI 1.32 to 1.45), and all-cause mortality (aHR 1.16, 95% CI 1.08 to 1.24) compared with women. Moreover, we observed a greater risk of adverse outcomes during the early pandemic (ie, February-April 2020) compared with later periods. In the ex-US cohort, the age and gender trends were similar; for the temporal trend, the highest proportion of patients with all-cause mortality were also in February-April 2020; however, the highest percentages of patients with IMV and ARDS/respiratory failure were in August-October 2020 followed by February-April 2020.

Conclusions

This study provided valuable information on the temporal trends of characteristics and outcomes of hospitalised adult COVID-19 patients in both USA and ex-USA. It also described the population at a potentially greater risk for worse clinical outcomes by identifying the age and gender differences. Together, the information could inform the prevention and treatment strategies of COVID-19. Furthermore, it can be used to raise public awareness of COVID-19's impact on vulnerable populations.

SUBMITTER: Zhu J

PROVIDER: S-EPMC8350974 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Publications

Characteristics and outcomes of hospitalised adults with COVID-19 in a Global Health Research Network: a cohort study.

Zhu Julia J Wei Zhongyuan Z Suryavanshi Manasi M Chen Xiu X Xia Qian Q Jiang Jenny J Ayodele Olulade O Bradbury Brian D BD Brooks Corinne C Brown Carolyn A CA Cheng Alvan A Critchlow Cathy W CW Devercelli Giovanna G Gandhi Vivek V Gondek Kathleen K Londhe Ajit A AA Ma Junjie J Jonsson-Funk Michele M Keenan Hillary A HA Manne Sudhakar S Ren Kaili K Sanders Lynn L Yu Peter P Zhang Jie J Zhou Linyun L Bao Ying Y

BMJ open 20210806 8

<h4>Objective</h4>To examine age, gender, and temporal differences in baseline characteristics and clinical outcomes of adult patients hospitalised with COVID-19.<h4>Design</h4>A cohort study using deidentified electronic medical records from a Global Research Network.<h4>Setting/participants</h4>67 456 adult patients hospitalised with COVID-19 from the USA; 7306 from Europe, Latin America and Asia-Pacific between February 2020 and January 2021.<h4>Results</h4>In the US cohort, compared with pat ...[more]

PMID: 34362806

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Dataset Information

Characteristics and outcomes of hospitalised adults with COVID-19 in a Global Health Research Network: a cohort study.

Objective

Design

Setting/participants

Results

Conclusions

Publications

Characteristics and outcomes of hospitalised adults with COVID-19 in a Global Health Research Network: a cohort study.

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