WD40 repeat 43 mediates cell survival, proliferation, migration and invasion via vimentin in colorectal cancer.

ABSTRACT:

Background

WD40 repeat (WDR)43 is an RNA-binding protein that belongs to the WDR domain protein family. Its biological function is largely unclear, particularly in colorectal cancer (CRC).

Methods

In the present study, we searched the TCGA database and found the correlation between WDR43 and CRC. Subsequently, the high expression of WDR43 in human clinical samples of CRC was validated and we further examined the biological functions of it in CRC cells. Finally, we explored potential downstream proteins or pathways and established subcutaneous xenograft model to verify our findings.

Results

Immunohistochemistry of 16 patient specimens confirmed that the expression of WDR43 was elevated in CRC. WDR43 knockdown was shown to increase apoptosis and inhibit the proliferatio

SUBMITTER: Li Z 

PROVIDER: S-EPMC8351096 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature