FBXW7 gene polymorphism is associated with type 2 diabetes in the Uygur population in Xinjiang, China.

ABSTRACT:

Background

FBXW7 gene expression is positively correlated with glycolipid metabolism and is associated with diabetes in animal models. In the current study, we focused on exploring whether genetic variants of the FBXW7 gene were associated with type 2 diabetes (T2DM) and the risk factors for T2DM in Uygur people in Xinjiang, China.

Methods

A total of 2164 Chinese Uygur subjects (673 T2DM patients and 1491 controls) were recruited for our case-control study, and four SNPs (rs10033601, rs2255137, rs2292743 and rs35311955) of the FBXW7 gene were genotyped using the improved multiplex ligation detection reaction (iMLDR) technique.

Results

Our study showed that the genotypes using the overdominant model (GA vs AA + GG) of rs10033601 and using the overdominant model (TA vs

SUBMITTER: Yan SQ 

PROVIDER: S-EPMC8351158 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature