CYB561D2 up-regulation activates STAT3 to induce immunosuppression and aggression in gliomas.

ABSTRACT:

Background

Fine tuned balance of reactive oxygen species (ROS) is essential for tumor cells and tumor cells use immune checkpoints to evade attack form immunity system. However, it's unclear whether there is any crosstalk between these two pathways. CYB561D2, an antioxidant protein, is part of 5-gene prognosis signature in gliomas and its involvement in gliomas is unknown. Here, we aim to provide a detailed characterization of CYB561D2 in gliomas.

Methods

CYB561D2 expression was measured in clinical samples of gilomas and normal tissues. The effects of CYB561D2 on immunity related genes and tumor behaviors were investigated in glioma cell lines with various in vitro and in vivo assays.

Results

CYB561D2 expression was enhanced in gliomas compared to control tissues. CY

SUBMITTER: Tao B 

PROVIDER: S-EPMC8351164 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature