Optimization of adiabatic pulses for pulsed arterial spin labeling at 7 tesla: Comparison with pseudo-continuous arterial spin labeling.

ABSTRACT:

Purpose

To optimize and evaluate adiabatic pulses for pulsed arterial spin labeling at ultrahigh field 7 tesla.

Methods

Four common adiabatic inversion pulses, including hyperbolic secant, wideband uniform rate smooth truncation, frequency offset corrected inversion, and time-resampled frequency offset corrected inversion pulses, were optimized based on a custom-defined loss function that included labeling efficiency and inversion band uniformity. The optimized pulses were implemented in flow-sensitive alternating inversion recovery sequences and tested on phantom and 11 healthy volunteers with 2 constraints: 1) specific absorption rate normalized; and 2) equal peak RF amplitude, respectively. A pseudo-continuous arterial spin labeling sequence was implemented for comparison

SUBMITTER: Wang K 

PROVIDER: S-EPMC8351166 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature