Extract of Cynomorium songaricum ameliorates mitochondrial ultrastructure impairments and dysfunction in two different in vitro models of Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, but there is still no effective way to stop or slow its progression. Our previous studies demonstrated that extract of Cynomorium songaricum (ECS), a Chinese herbal medicine, had neuroprotective effects in AD models in vivo. However, the pharmacological mechanism of ECS in AD is still unclear.

Methods

To study the mechanisms of action of the effects of ECS on AD, we used Aβ_25-35- and H₂O₂-exposed HT22 cells to mimic specific stages of AD in vitro. The mitochondrial membrane potential (MMP), intracellular ATP, intracellular reactive oxygen species (ROS), and expression levels of mitochondrial dynamics-related proteins in each group were examined. Further

SUBMITTER: Cheng D 

PROVIDER: S-EPMC8351341 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature