Reasons for undergoing amyloid imaging among cognitively unimpaired older adults.

ABSTRACT:

Objectives

Preclinical Alzheimer's disease (AD) clinical trials screen cognitively unimpaired older adults for biomarker criteria and disclose their results. We examined whether participants in the Anti-Amyloid Treatment in Asymptomatic Alzheimer's disease Study with "elevated" and "not elevated" amyloid differed in scores on the "Views and Perceptions of Amyloid Imaging" questionnaire. We hypothesized that, prior to disclosure, those with elevated amyloid would score higher than those with not elevated amyloid. We also quantified how responses changed after result disclosure.

Methods

We assessed data from 4327 individuals who completed the questionnaire at screening visit 1 and after amyloid disclosure. We used linear regression models to assess the relationship between que

SUBMITTER: Ryan MM 

PROVIDER: S-EPMC8351390 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature