Distinct progression patterns across Parkinson disease clinical subtypes.

ABSTRACT:

Objective

To examine specific symptom progression patterns and possible disease staging in Parkinson disease clinical subtypes.

Methods

We recently identified Parkinson disease clinical subtypes based on comprehensive behavioral evaluations, "Motor Only," "Psychiatric & Motor," and "Cognitive & Motor," which differed in dementia and mortality rates. Parkinson disease participants ("Motor Only": n = 61, "Psychiatric & Motor": n = 17, "Cognitive & Motor": n = 70) and controls (n = 55) completed longitudinal, comprehensive motor, cognitive, and psychiatric evaluations (average follow-up = 4.6 years). Hierarchical linear modeling examined group differences in symptom progression. A three-way interaction among time, group, and symptom duration (or baseline age, separately) was in

SUBMITTER: Myers PS 

PROVIDER: S-EPMC8351397 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature