Genetic determinants of multiple myeloma risk within the Wnt/beta-catenin signaling pathway.

ABSTRACT:

Background

Aberrant Wnt/beta-catenin pathway activation is implicated in Multiple Myeloma (MM) development, but little is known if genetic variants within this pathway contribute to MM susceptibility.

Methods

We performed a discovery candidate pathway analysis in 269 non-Hispanic white MM cases and 272 controls focusing on 171 variants selected from 26 core genes within the Wnt/beta-catenin pathway. Significant candidate variants (P < 0.05) were selected for validation in internal and external non-Hispanic white populations totaling 818 cases and 1209 controls. We also examined significant variants in non-Hispanic black and Hispanic case/control study populations to identify potential differences by race/ethnicity. Possible biological functions of candidate variants were pre

SUBMITTER: Belachew AA 

PROVIDER: S-EPMC8351401 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature