Proteome profiling of human placenta reveals developmental stage-dependent alterations in protein signature.

ABSTRACT:

Introduction

Placenta is a complex organ that plays a significant role in the maintenance of pregnancy health. It is a dynamic organ that undergoes dramatic changes in growth and development at different stages of gestation. In the first-trimester, the conceptus develops in a low oxygen environment that favors organogenesis in the embryo and cell proliferation and angiogenesis in the placenta; later in pregnancy, higher oxygen concentration is required to support the rapid growth of the fetus. This oxygen transition, which appears unique to the human placenta, must be finely tuned through successive rounds of protein signature alterations. This study compares placental proteome in normal first-trimester (FT) and term human placentas (TP).

Methods

Normal human first-trimester

SUBMITTER: Khorami Sarvestani S 

PROVIDER: S-EPMC8351416 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature