Circulating lymphocyte subsets as promising biomarkers to identify septic patients at higher risk of unfavorable outcome.

ABSTRACT:

Background

Early recognition of patients hospitalized for sepsis at higher risk of poor clinical outcome is a mandatory task and many studies suggested that indicators of the immune status may be useful for this purpose. We performed a retrospective, monocentric cohort study to evaluate whether lymphocyte subsets may be useful in predicting in-hospital mortality of septic patients.

Methods

Data of all consecutive patients with a diagnosis of sepsis at discharge and an available peripherical blood lymphocyte subset (CD4, CD8, CD16/CD56 and CD19) analysis at hospital entry were retrospectively collected between January 2015 and August 2018. Clinical characteristics of patients, past medical history and other laboratory parameters were also considered.

Results

Two-hundre

SUBMITTER: Polilli E 

PROVIDER: S-EPMC8351421 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature