Joint Associations of Maternal-Fetal APOL1 Genotypes and Maternal Country of Origin With Preeclampsia Risk.

ABSTRACT:

Rationale & objectives

Preeclampsia, which disproportionately affects Black women, is a leading cause of preterm delivery and risk for future hypertension and chronic kidney disease (CKD). Apolipoprotein L1 (APOL1) kidney risk alleles, common among Black individuals, contribute substantially to CKD disparities. Given the strong link between preeclampsia and CKD, we investigated whether maternal and fetal APOL1 risk alleles can jointly influence preeclampsia risk, and explored potential modifiers of the association between APOL1 and preeclampsia.

Study design

Nested case-control study.

Setting & participants

426 Black mother-infant pairs (275 African Americans and 151 Haitians) from the Boston Birth Cohort.

Exposure

Maternal and fetal APOL1 risk alleles.

Outc

SUBMITTER: Hong X 

PROVIDER: S-EPMC8351532 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature