Aspergillus nidulans biofilm formation modifies cellular architecture and enables light-activated autophagy.

ABSTRACT: After growing on surfaces, including those of medical and industrial importance, fungal biofilms self-generate internal microenvironments. We previously reported that gaseous microenvironments around founder Aspergillus nidulans cells change during biofilm formation causing microtubules to disassemble under control of the hypoxic transcription factor SrbA. Here we investigate if biofilm formation might also promote changes to structures involved in exocytosis and endocytosis. During biofilm formation, the endoplasmic reticulum (ER) remained intact but ER exit sites and the Golgi apparatus were modified as were endocytic actin patches. The biofilm-driven changes required the SrbA hypoxic transcription factor and could be triggered by nitric oxide, further implicating gaseous regulati

SUBMITTER: Lingo DE 

PROVIDER: S-EPMC8351559 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature