Establishment of a ferroptosis-related gene signature for prognosis in lung adenocarcinoma patients.

ABSTRACT:

Objective

Lung cancer is the most common malignancy worldwide and exhibits both high morbidity and mortality. In recent years, scientists have made substantial breakthroughs in the early diagnosis and treatment of lung adenocarcinoma (LUAD), however, patient prognosis still shows vast individual differences. In this study, bioinformatics methods were used to identify and analyze ferroptosis-related genes to establish an effective signature for predicting prognosis in LUAD patients.

Methods

The gene expression profiles of LUAD patients with complete clinical and follow-up information were downloaded from two public databases, univariate Cox regression and multivariate Cox regression analysis were used to obtain ferroptosis-related genes for constructing the prognos tic risk m

SUBMITTER: Cai J 

PROVIDER: S-EPMC8351575 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature