High CD39 expression is associated with the non-muscle-invasive phenotype of human bladder cancer.

ABSTRACT:

Background

An accurate prediction of progression is critical to define the management of bladder cancer (BC). The ectonucleotidases CD39 and CD73 play strategic roles in calibrating purinergic signals via an extracellular balance between ATP and adenosine. The altered expression of these enzymes plays a potential role in tumor invasion and metastasis, therefore, has been proposed to be used for prognosis of solid tumor. In BC this is not yet clear.

Objective

This study aimed to evaluate CD39 and CD73 expression in a cohort of patients with non-muscle-invasive (NMI) and muscle-invasive (MI) BC regard to its association with clinicopathological features.

Materials and methods

Retrospective clinical follow-up data and primary urothelial BC specimens of 162 patients were

SUBMITTER: Ferreira JM 

PROVIDER: S-EPMC8351603 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature