Polimorfismo de genes de citocinas: ¿factores de riesgo cardiovascular en la poblacion venezolana?

ABSTRACT:

Objective

To examine whether the polymorphisms of the IL6, TNFA and IL10 genes represent a risk marker for acute myocardial infarction (AMI) and to analyze their correlation with risk factors, age of occurrence and type of AMI.

Method

Association study that included 310 unrelated Venezuelan individuals, grouped in 190 patients with AMI and 120 controls with or without cardiovascular risk factors. The IL6-174 G/C (rs1800795), TNFA -308 G/A (rs1800629), and IL10-1082 A/G (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872) polymorphisms were determined using the polymerase chain reaction technique with sequence-specific primers.

Results

Comparison of genotypic and allelic frequencies, using adjusted logistic regression analysis for risk factors, showed a significa

SUBMITTER: Fernandez-Mestre M 

PROVIDER: S-EPMC8351660 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature