Plasma metabolites changes in male heroin addicts during acute and protracted withdrawal.

ABSTRACT:

Background

Heroin addiction and withdrawal have been associated with an increased risk for infectious diseases and psychological complications. However, the changes of metabolites in heroin addicts during withdrawal remain largely unknown.

Methods

A total of 50 participants including 20 heroin addicts with acute abstinence stage, 15 with protracted abstinence stage and 15 healthy controls, were recruited. We performed metabolic profiling of plasma samples based on ultraperformance liquid chromatography coupled to tandem mass spectrometry to explore the potential biomarkers and mechanisms of heroin withdrawal.

Results

Among the metabolites analyzed, omega-6 polyunsaturated fatty acids (linoleic acid, dihomo-gamma-linolenic acid, arachidonic acid, n-6 docosapentaenoic a

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC8351709 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature