Hippocampal and striatal responses during motor learning are modulated by prefrontal cortex stimulation.

ABSTRACT: While it is widely accepted that motor sequence learning (MSL) is supported by a prefrontal-mediated interaction between hippocampal and striatal networks, it remains unknown whether the functional responses of these networks can be modulated in humans with targeted experimental interventions. The present proof-of-concept study employed a multimodal neuroimaging approach, including functional magnetic resonance (MR) imaging and MR spectroscopy, to investigate whether individually-tailored theta-burst stimulation of the dorsolateral prefrontal cortex can modulate responses in the hippocampus and the basal ganglia during motor learning. Our results indicate that while stimulation did not modulate motor performance nor task-related brain activity, it influenced connectivity patterns within hi

SUBMITTER: Gann MA 

PROVIDER: S-EPMC8351752 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature