Association between APOC3 polymorphisms and non-alcoholic fatty liver disease risk: a meta-analysis.

ABSTRACT:

Background and aim

The apolipoprotein C3 (APOC3) polymorphism has been reported to predispose to non-alcoholic fatty liver disease (NAFLD). However, the results remain inconclusive. This meta-analysis aimed to provide insights into the association between APOC3 polymorphisms and NAFLD risk.

Methods

Studies with terms "NALFD" and "APOC3" were retrieved from PubMed, Web of Science, CNKI and Wanfang databases up to August 1, 2019. Pooled odds ratio (OR) and 95% confidence interval (95% CI) for the association of APOC3 polymorphisms and NAFLD risk were calculated using fixed and random-effects models.

Results

A total of twelve studies from eleven articles were included. Of them, eight studies (1750 cases and 2181 controls) reported the strong association of variant rs2854

SUBMITTER: Wang J 

PROVIDER: S-EPMC8351815 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature