Association of FADS2 rs174575 gene polymorphism and insulin resistance in type 2 diabetes mellitus.

ABSTRACT:

Background

Many risk factors contribute to the pathogenesis of diabetes. Gene and lifestyle factors are considered to be the major contributors. A dietary pattern is attributed to be one of the lifestyle risk factors favoring diabetes. The present study aims to find an association between fatty acid desaturase (FADS) gene polymorphism and glycemic profile in type 2 diabetes mellitus (T2DM).

Methodology

A total of 429 subjects were included in the study on the basis of inclusion and exclusion criteria, of which 213 and 216 subjects were diabetic and control, respectively. Body mass index was calculated. Fasting plasma glucose, glycated hemoglobin (HbA1c) and insulin were measured using commercially available kits. rs174575 of FADS2 was selected based on previous publications

SUBMITTER: Shetty SS 

PROVIDER: S-EPMC8351823 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature