Multidimensional analysis of immune responses identified biomarkers of recent Mycobacterium tuberculosis infection.

ABSTRACT: The risk of tuberculosis (TB) disease is higher in individuals with recent Mycobacterium tuberculosis (M.tb) infection compared to individuals with more remote, established infection. We aimed to define blood-based biomarkers to distinguish between recent and remote infection, which would allow targeting of recently infected individuals for preventive TB treatment. We hypothesized that integration of multiple immune measurements would outperform the diagnostic performance of a single biomarker. Analysis was performed on different components of the immune system, including adaptive and innate responses to mycobacteria, measured on recently and remotely M.tb infected adolescents. The datasets were standardized using variance stabilizing scaling and missing values were imputed using a multipl

SUBMITTER: Lloyd T 

PROVIDER: S-EPMC8351927 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature