The relationship of tidal volume and driving pressure with mortality in hypoxic patients receiving mechanical ventilation.

ABSTRACT:

Purpose

To determine whether tidal volume/predicted body weight (TV/PBW) or driving pressure (DP) are associated with mortality in a heterogeneous population of hypoxic mechanically ventilated patients.

Methods

A retrospective cohort study involving 18 intensive care units included consecutive patients ≥18 years old, receiving mechanical ventilation for ≥3 days, with a PaO2/FiO2 ratio ≤300 mmHg, whether or not they met full criteria for ARDS. The main outcome was hospital mortality. Multiple logistic regression (MLR) incorporated TV/PBW, DP, and potential confounders including age, APACHE IVa® predicted hospital mortality, respiratory system compliance (CRS), and PaO2/FiO2. Predetermined strata of TV/PBW were compared using MLR.

Results

Our cohort comprised 5,167 pati

SUBMITTER: Raschke RA 

PROVIDER: S-EPMC8351937 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature