Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase.

ABSTRACT: In order to sustain a persistent infection, Mycobacterium tuberculosis (Mtb) must adapt to a changing environment that is shaped by the developing immune response. This necessity to adapt is evident in the flexibility of many aspects of Mtb metabolism, including a respiratory chain that consists of two distinct terminal cytochrome oxidase complexes. Under the conditions tested thus far, the bc1/aa3 complex appears to play a dominant role, while the alternative bd oxidase is largely redundant. However, the presence of two terminal oxidases in this obligate pathogen implies that respiratory requirements might change during infection. We report that the cytochrome bd oxidase is specifically required for resisting the adaptive immune response. While the bd oxidase was dispensable for growth in

SUBMITTER: Cai Y 

PROVIDER: S-EPMC8351954 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature