Impact of Cancer Therapy-Related Cardiac Dysfunction on Risk of Heart Failure in Pregnancy.

ABSTRACT:

Background

Cancer treatment can lead to left ventricular (LV) dysfunction in female cancer survivors of reproductive age, and pregnancy-related hemodynamic stress may result in LV dysfunction or heart failure (HF).

Objectives

We performed a systematic review and meta-analysis to determine the incidence of LV systolic dysfunction or HF during or soon after pregnancy in cancer survivors and evaluated the impact of history of cancer therapeutics-related cardiac dysfunction (CTRCD).

Methods

We systematically searched electronic databases (MEDLINE and EMBASE) from inception to January 2020 to identify cohort studies that examined cardiac disease in pregnant cancer survivors. Meta-analysis was performed using the inverse-variance fixed effects method. Potential sources of h

SUBMITTER: Nolan M 

PROVIDER: S-EPMC8352036 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature