Genetic susceptibility to multiple sclerosis in African Americans.

ABSTRACT:

Objective

To explore the nature of genetic-susceptibility to multiple sclerosis (MS) in African-Americans.

Background

Recently, the number of genetic-associations with MS has exploded although the MS-associations of specific haplotypes within the major histocompatibility complex (MHC) have been known for decades. For example, the haplotypes HLA-DRB1*15:01~HLA-DQB1*06:02, and HLA-DRB1*03:01~ HLA-DQB1*02:01 have odds ratios (ORs) for an MS-association orders of magnitude stronger than many of these newly-discovered associations. Nevertheless, all these haplotypes are part of much larger conserved extended haplotypes (CEHs), which span both the Class I and Class II MHC regions. African-Americans are at greater risk of developing MS compared to a native Africans but at lesser ri

SUBMITTER: Goodin DS 

PROVIDER: S-EPMC8352072 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature