3-Year Follow-Up of Radiation-Associated Changes in Diastolic Function by Speckle Tracking Echocardiography.

ABSTRACT:

Background

Radiation therapy (RT) results in myocardial changes consisting of diffuse fibrosis, which may result in changes in diastolic function.

Objectives

The aim of this study was to explore RT-associated changes in left ventricular (LV) diastolic function.

Methods

Sixty chemotherapy-naive patients with left-sided, early-stage breast cancer were studied with speckle tracking echocardiography at 3 time points: prior to, immediately after, and 3 years after RT. Global and regional early diastolic strain rate (SRe) were quantified, as were parameters of systolic function.

Results

Regional changes in SRe, particularly the apical and anteroseptal segments, were observed over time and were more evident than global changes. The apical SRe declined from a median of

SUBMITTER: Tuohinen SS 

PROVIDER: S-EPMC8352342 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature