Combinatorial Strategies to Target Molecular and Signaling Pathways to Disarm Cancer Stem Cells.

ABSTRACT: Cancer is an urgent public health issue with a very huge number of cases all over the world expected to increase by 2040. Despite improved diagnosis and therapeutic protocols, it remains the main leading cause of death in the world. Cancer stem cells (CSCs) constitute a tumor subpopulation defined by ability to self-renewal and to generate the heterogeneous and differentiated cell lineages that form the tumor bulk. These cells represent a major concern in cancer treatment due to resistance to conventional protocols of radiotherapy, chemotherapy and molecular targeted therapy. In fact, although partial or complete tumor regression can be achieved in patients, these responses are often followed by cancer relapse due to the expansion of CSCs population. The aberrant activation of developmenta

SUBMITTER: Catara G 

PROVIDER: S-EPMC8352560 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature