Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains.

ABSTRACT:

Background

The degree of heterotypic immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains is a major determinant of the spread of emerging variants and the success of vaccination campaigns, but remains incompletely understood.

Methods

We examined the immunogenicity of SARS-CoV-2 variant B.1.1.7 (Alpha) that arose in the United Kingdom and spread globally. We determined titres of spike glycoprotein-binding antibodies and authentic virus neutralising antibodies induced by B.1.1.7 infection to infer homotypic and heterotypic immunity.

Results

Antibodies elicited by B.1.1.7 infection exhibited significantly reduced recognition and neutralisation of parental strains or of the South Africa variant B.1.351 (Beta) than of the infecting vari

SUBMITTER: Faulkner N 

PROVIDER: S-EPMC8352583 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature