Natural variation in the consequences of gene overexpression and its implications for evolutionary trajectories.

ABSTRACT: Copy number variation through gene or chromosome amplification provides a route for rapid phenotypic variation and supports the long-term evolution of gene functions. Although the evolutionary importance of copy-number variation is known, little is understood about how genetic background influences its tolerance. Here, we measured fitness costs of over 4000 overexpressed genes in 15 Saccharomyces cerevisiae strains representing different lineages, to explore natural variation in tolerating gene overexpression (OE). Strain-specific effects dominated the fitness costs of gene OE. We report global differences in the consequences of gene OE, independent of the amplified gene, as well as gene-specific effects that were dependent on the genetic background. Natural variation in the respons

SUBMITTER: Robinson D 

PROVIDER: S-EPMC8352584 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature