Computational study of non-conductive selectivity filter conformations and C-type inactivation in a voltage-dependent potassium channel.

ABSTRACT: C-type inactivation is a time-dependent process of great physiological significance that is observed in a large class of K+ channels. Experimental and computational studies of the pH-activated KcsA channel show that the functional C-type inactivated state, for this channel, is associated with a structural constriction of the selectivity filter at the level of the central glycine residue in the signature sequence, TTV(G)YGD. The structural constriction is allosterically promoted by the wide opening of the intracellular activation gate. However, whether this is a universal mechanism for C-type inactivation has not been established with certainty because similar constricted structures have not been observed for other K+ channels. Seeking to ascertain the general plausibility of the constricte

SUBMITTER: Li J 

PROVIDER: S-EPMC8352720 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature