An effective model of endogenous clocks and external stimuli determining circadian rhythms.

ABSTRACT: Circadian endogenous clocks of eukaryotic organisms are an established and rapidly developing research field. To investigate and simulate in an effective model the effect of external stimuli on such clocks and their components we developed a software framework for download and simulation. The application is useful to understand the different involved effects in a mathematical simple and effective model. This concerns the effects of Zeitgebers, feedback loops and further modifying components. We start from a known mathematical oscillator model, which is based on experimental molecular findings. This is extended with an effective framework that includes the impact of external stimuli on the circadian oscillations including high dose pharmacological treatment. In particular, the external stim

SUBMITTER: Breitenbach T 

PROVIDER: S-EPMC8352901 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature