Effect of liquid cooling on PCR performance with the parametric study of cross-section shapes of microchannels.

ABSTRACT: In recent years, PCR-based methods as a rapid and high accurate technique in the industry and medical fields have been expanded rapidly. Where we are faced with the COVID-19 pandemic, the necessity of a rapid diagnosis has felt more than ever. In the current interdisciplinary study, we have proposed, developed, and characterized a state-of-the-art liquid cooling design to accelerate the PCR procedure. A numerical simulation approach is utilized to evaluate 15 different cross-sections of the microchannel heat sink and select the best shape to achieve this goal. Also, crucial heat sink parameters are characterized, e.g., heat transfer coefficient, pressure drop, performance evaluation criteria, and fluid flow. The achieved result showed that the circular cross-section is the most efficient s

SUBMITTER: Alihosseini Y 

PROVIDER: S-EPMC8352922 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature