CREB signaling activity correlates with differentiation and survival in medulloblastoma.

ABSTRACT: While there has been significant progress in the molecular characterization of the childhood brain cancer medulloblastoma, the tumor proteome remains less explored. However, it is important to obtain a complete understanding of medulloblastoma protein biology, since interactions between proteins represent potential new drug targets. Using previously generated phosphoprotein signaling-profiles of a large cohort of primary medulloblastoma, we discovered that phosphorylation of transcription factor CREB strongly correlates with medulloblastoma survival and associates with a differentiation phenotype. We further found that during normal cerebellar development, phosphorylated CREB was selectively expressed in differentiating cerebellar granule neuron progenitor (CGNP) cells. In line, we observe

SUBMITTER: Armandari I 

PROVIDER: S-EPMC8352923 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature