Increased frequency of Th17 cells and IL-17 levels are associated with low bone mineral density in postmenopausal women.

ABSTRACT: Osteoporosis is one of the chronic and often neglected bone diseases in aging postmenopausal women that affect the quality of life. Studies on ovariectomized mice models indicated the reciprocal role of Th17 cells and Treg cells in the aetiology of osteoporosis. While Th17 cells promote osteoclastogenesis, Treg cells exhibit anti-osteoclastogenic activity. This exploratory study aimed to determine the difference in the frequency of these T-cell subtypes in pre-and postmenopausal women and to examine their association with BMD. In our study, the frequency of Treg cells, analyzed by flow cytometry, did not differ between pre-and postmenopausal women. However, plasma levels of IL-10 along with IL-10⁺CD4⁺T cells were higher in post- compared to premenopausal women. The fr

SUBMITTER: Bhadricha H 

PROVIDER: S-EPMC8352954 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature