Ontology highlight
ABSTRACT:
SUBMITTER: Xu L
PROVIDER: S-EPMC8353022 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Xu Lan L Xu Weiwei W Li Duan D Yu Xiaoxia X Gao Fei F Qin Yingying Y Yang Yajuan Y Zhao Shidou S
Cell death & disease 20210809 8
FANCI is an essential component of Fanconi anemia pathway, which is responsible for the repair of DNA interstrand cross-links (ICLs). As an evolutionarily related partner of FANCD2, FANCI functions together with FANCD2 downstream of FA core complex. Currently, growing evidences showed that the essential role of FA pathway in male fertility. However, the underlying mechanisms for FANCI in regulating spermatogenesis remain unclear. In the present study, we found that the male Fanci<sup>-/-</sup> m ...[more]