Deuteron Chemical Exchange Saturation Transfer for the Detection of Slow Motions in Rotating Solids.

ABSTRACT: We utilized the ²H Chemical Exchange Saturation Transfer (CEST) technique under magic angle spinning (MAS) conditions to demonstrate the feasibility of the method for studies of slow motions in the solid state. For the quadrupolar anisotropic interaction, the essence of CEST is to scan the saturation pattern over a range of offsets corresponding to the entire spectral region(s) for all conformational states involved, which translates into a range of -60-+ 60 kHz for methyl groups. Rotary resonances occur when the offsets are at half-and full-integer of the MAS rates. The choice of the optimal MAS rate is governed by the condition to reduce the number of rotary resonances in the CEST profile patterns and retain a sufficiently large quadrupolar interaction active under MAS to main

SUBMITTER: Vugmeyster L 

PROVIDER: S-EPMC8353179 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature