Multi-omics comparisons of different forms of centronuclear myopathies and the effects of several therapeutic strategies.

ABSTRACT: Omics analyses are powerful methods to obtain an integrated view of complex biological processes, disease progression, or therapy efficiency. However, few studies have compared different disease forms and different therapy strategies to define the common molecular signatures representing the most significant implicated pathways. In this study, we used RNA sequencing and mass spectrometry to profile the transcriptomes and proteomes of mouse models for three forms of centronuclear myopathies (CNMs), untreated or treated with either a drug (tamoxifen), antisense oligonucleotides reducing the level of dynamin 2 (DNM2), or following modulation of DNM2 or amphiphysin 2 (BIN1) through genetic crosses. Unsupervised analysis and differential gene and protein expression were performed to retrieve CN

SUBMITTER: Djeddi S 

PROVIDER: S-EPMC8353243 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature