Evaluation of Oncogene NUP37 as a Potential Novel Biomarker in Breast Cancer.

ABSTRACT:

Purpose

There is an urgent need to identify oncogenes that may be beneficial to diagnose and develop target therapy for breast cancer.

Methods

Based on the GEO database, DECenter was used to screen the differentially overexpressed genes in breast cancer samples. Search Tool for the Retrieval of Interacting Genes and Cytoscape were performed to construct the PPI network to predict the hub gene. Functional and pathway enrichment were performed based on GO analysis. GEO2R, Oncomine, human tissue microarray staining, and western blot were applied to confirm the expression of NUP37. The association between NUP37 expression and prognosis in patients with breast cancer were assessed using the Kaplan-Meier plotter online tool and OncoLnc. siRNAs were used to knock down NUP37 and eva

SUBMITTER: Li K 

PROVIDER: S-EPMC8353244 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature