Altered Metabolic Phenotype of Immune Cells in a Spontaneous Autoimmune Uveitis Model.

ABSTRACT: As one of the leading causes of blindness worldwide, uveitis is an important disease. The exact pathogenesis of autoimmune uveitis is not entirely elucidated to date. Equine recurrent uveitis (ERU) represents the only spontaneous animal model for autoimmune uveitis in humans. As the metabolism of immune cells is an emerging field in research and gains more and more significance to take part in the pathogenesis of various diseases, we conducted experiments to investigate the metabolism of immune cells of ERU cases and healthy controls. To our knowledge, the link between a deviant immunometabolism and the pathogenesis of autoimmune uveitis was not investigated so far. We showed that PBMC of ERU cases had a more active metabolic phenotype in basal state by upregulating both the oxidative phos

SUBMITTER: Barfußer C 

PROVIDER: S-EPMC8353246 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature