Gene-Edited Interleukin CAR-T Cells Therapy in the Treatment of Malignancies: Present and Future.

ABSTRACT: In recent years, chimeric antigen receptor T cells (CAR-T cells) have been faced with the problems of weak proliferation and poor persistence in the treatment of some malignancies. Researchers have been trying to perfect the function of CAR-T by genetically modifying its structure. In addition to the participation of T cell receptor (TCR) and costimulatory signals, immune cytokines also exert a decisive role in the activation and proliferation of T cells. Therefore, genetic engineering strategies were used to generate cytokines to enhance tumor killing function of CAR-T cells. When CAR-T cells are in contact with target tumor tissue, the proliferation ability and persistence of T cells can be improved by structurally or inductively releasing immunoregulatory molecules to the tumor region.

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8353254 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature