Long Non-coding RNA: An Emerging Contributor and Potential Therapeutic Target in Renal Fibrosis.

ABSTRACT: Renal fibrosis (RF) is a pathological process that culminates in terminal renal failure in chronic kidney disease (CKD). Fibrosis contributes to progressive and irreversible decline in renal function. However, the molecular mechanisms involved in RF are complex and remain poorly understood. Long non-coding RNAs (lncRNAs) are a major type of non-coding RNAs, which significantly affect various disease processes, cellular homeostasis, and development through multiple mechanisms. Recent investigations have implicated aberrantly expressed lncRNA in RF development and progression, suggesting that lncRNAs play a crucial role in determining the clinical manifestation of RF. In this review, we comprehensively evaluated the recently published articles on lncRNAs in RF, discussed the potential applic

SUBMITTER: Xia W 

PROVIDER: S-EPMC8353329 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature