Placental DNA methylation marks are associated with maternal depressive symptoms during early pregnancy.

ABSTRACT: Maternal depressive symptoms during pregnancy are a significant risk factor for adverse developmental and health outcomes of the offspring. The molecular mechanisms mediating the long-term effects of this exposure are not well understood. Previous studies have found association between prenatal exposure to maternal psychological distress and placental DNA methylation of candidate genes, which can influence placental barrier function and development of the fetus. Our objective in this study was to determine epigenome wide association of maternal depressive symptoms in early pregnancy with the placental DNA methylation. For this purpose we examined DNA methylomes of 92 placental samples by using reduced representation bisulfite sequencing. The placental samples were collected after deliverie

SUBMITTER: Lund RJ 

PROVIDER: S-EPMC8353413 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature