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Engineered T Cell Therapy for Gynecologic Malignancies: Challenges and Opportunities.

ABSTRACT: Gynecologic malignancies, mainly including ovarian cancer, cervical cancer and endometrial cancer, are leading causes of death among women worldwide with high incidence and mortality rate. Recently, adoptive T cell therapy (ACT) using engineered T cells redirected by genes which encode for tumor-specific T cell receptors (TCRs) or chimeric antigen receptors (CARs) has demonstrated a delightful potency in B cell lymphoma treatment. Researches impelling ACT to be applied in treating solid tumors like gynecologic tumors are ongoing. This review summarizes the preclinical research and clinical application of engineered T cells therapy for gynecologic cancer in order to arouse new thoughts for remedies of this disease.

SUBMITTER: Xu Y

PROVIDER: S-EPMC8353443 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Engineered T Cell Therapy for Gynecologic Malignancies: Challenges and Opportunities.

Xu Yifan Y Jiang Jin J Wang Yutong Y Wang Wei W Li Haokun H Lai Wenyu W Zhou Zhipeng Z Zhu Wei W Xiang Zheng Z Wang Zhiming Z Zhu Zhe Z Yu Lingfeng L Huang Xiaolan X Zheng Hua H Wu Sha S

Frontiers in immunology 20210727

Gynecologic malignancies, mainly including ovarian cancer, cervical cancer and endometrial cancer, are leading causes of death among women worldwide with high incidence and mortality rate. Recently, adoptive T cell therapy (ACT) using engineered T cells redirected by genes which encode for tumor-specific T cell receptors (TCRs) or chimeric antigen receptors (CARs) has demonstrated a delightful potency in B cell lymphoma treatment. Researches impelling ACT to be applied in treating solid tumors l ...[more]

PMID: 34386017

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