Revisiting the Radiobiology of Targeted Alpha Therapy.

ABSTRACT: Targeted alpha therapy (TAT) using alpha particle-emitting radionuclides is in the spotlight after the approval of ²²³RaCl₂ for patients with metastatic castration-resistant prostate cancer and the development of several alpha emitter-based radiopharmaceuticals. It is acknowledged that alpha particles are highly cytotoxic because they produce complex DNA lesions. Hence, the nucleus is considered their critical target, and many studies did not report any effect in other subcellular compartments. Moreover, their physical features, including their range in tissues (<100 μm) and their linear energy transfer (50-230 keV/μm), are well-characterized. Theoretically, TAT is indicated for very small-volume, disseminated tumors (e.g., micrometastases, circulating tumor cells). M

SUBMITTER: Pouget JP 

PROVIDER: S-EPMC8353448 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature