Rac-dependent feedforward autoactivation of NOX2 leads to oxidative burst.

ABSTRACT: NADPH oxidase 2 (NOX2) produces the superoxide anion radical (O₂^-), which has functions in both cell signaling and immune defense. NOX2 is a multimeric-protein complex consisting of several protein subunits including the GTPase Rac. NOX2 uniquely facilitates an oxidative burst, which is described by initially slow O₂^- production, which increases over time. The NOX2 oxidative burst is considered critical to immune defense because it enables expedited O₂^- production in response to infections. However, the mechanism of the initiation and progression of this oxidative burst and its implications for regulation of NOX2 have not been clarified. In this study, we show that the NOX2 oxidative burst is a result of autoactivation of NO

SUBMITTER: Hoang HM 

PROVIDER: S-EPMC8353492 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature