Oscillation of Cdc20-APC/C-mediated CAMDI stability is critical for cortical neuron migration.

ABSTRACT: Radial migration during cortical development is required for formation of the six-layered structure of the mammalian cortex. Defective migration of neurons is linked to several developmental disorders such as autism and schizophrenia. A unique swollen structure called the dilation is formed in migrating neurons and is required for movement of the centrosome and nucleus. However, the detailed molecular mechanism by which this dilation forms is unclear. We report that CAMDI, a gene whose deletion is associated with psychiatric behavior, is degraded by cell division cycle protein 20 (Cdc20)-anaphase-promoting complex/cyclosome (APC/C) cell-cycle machinery after centrosome migration into the dilation in mouse brain development. We also show that CAMDI is restabilized in the dilation until the

SUBMITTER: Okuda S 

PROVIDER: S-EPMC8353494 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature