Ontology highlight
ABSTRACT:
SUBMITTER: Savorani C
PROVIDER: S-EPMC8353525 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Savorani Cecilia C Malinverno Matteo M Seccia Roberta R Maderna Claudio C Giannotta Monica M Terreran Linda L Mastrapasqua Eleonora E Campaner Stefano S Dejana Elisabetta E Giampietro Costanza C
Journal of cell science 20210802 15
Endothelial-to-mesenchymal transition (EndMT) is the biological process through which endothelial cells transdifferentiate into mesenchymal cells. During embryo development, EndMT regulates endocardial cushion formation via TGFβ/BMP signaling. In adults, EndMT is mainly activated during pathological conditions. Hence, it is necessary to characterize molecular regulators cooperating with TGFβ signaling in driving EndMT, to identify potential novel therapeutic targets to treat these pathologies. H ...[more]