Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.

ABSTRACT: The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Personalised Responses to Dietary Composition Trial (PREDICT 1) study, whose detailed long-term diet information, as well as hundreds of fasting and same-meal postprandial cardiometabolic blood marker measurements were available. We found many significant associations between microbes and specific nutrients, foods, food groups and general dietary indices, which were driven especially by the presence and diversity of healthy and plant-based foods. Microbial biomarkers of obesity were reproducible across external publicly available cohorts and in agre

SUBMITTER: Asnicar F 

PROVIDER: S-EPMC8353542 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature