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In Vitro Inhibition of Alphaviruses by Lycorine.

ABSTRACT: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. As an emerging virus, CHIKV imposes a threat to public health. Currently, there are no vaccines or antivirals available for the prevention of CHIKV infection. Lycorine, an alkaloid from Amaryllidaceae plants, has antiviral activity against a number of viruses such as coronavirus, flavivirus and enterovirus. In this study, we found that lycorine could inhibit CHIKV in cell culture at a concentration of 10 μmol/L without apparent cytotoxicity. In addition, it exhibited broad-spectrum anti-alphavirus activity, including Sindbis virus (SINV), Semliki Forest virus (SFV), and Venezuelan equine encephalomyelitis virus (VEEV). The time of addition studies indicated that lycorine functions at an early post-entry stage of CHIKV life cycle. The results based on two different CHIKV replicons provided further evidence that lycorine exerts its antiviral activity mainly by inhibiting CHIKV translation. Overall, our study extends the antiviral spectrum of lycorine.

SUBMITTER: Li N 

PROVIDER: S-EPMC8353614 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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In Vitro Inhibition of Alphaviruses by Lycorine.

Li Na N   Wang Zhen Z   Wang Rui R   Zhang Zhe-Rui ZR   Zhang Ya-Nan YN   Deng Cheng-Lin CL   Zhang Bo B   Shang Lu-Qing LQ   Ye Han-Qing HQ  

Virologica Sinica 20210810 6

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. As an emerging virus, CHIKV imposes a threat to public health. Currently, there are no vaccines or antivirals available for the prevention of CHIKV infection. Lycorine, an alkaloid from Amaryllidaceae plants, has antiviral activity against a number of viruses such as coronavirus, flavivirus and enterovirus. In this study, we found that lycorine could inhibit CHIKV in cell culture at a concentration of 10 μmol/L without apparent cytotoxici  ...[more]

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