Integrated Multi-Omics Analysis of Mechanisms Underlying Yeast Ethanol Tolerance.

ABSTRACT: For yeast cells, tolerance to high levels of ethanol is vital both in their natural environment and in industrially relevant conditions. We recently genotyped experimentally evolved yeast strains adapted to high levels of ethanol and identified mutations linked to ethanol tolerance. In this study, by integrating genomic sequencing data with quantitative proteomics profiles from six evolved strains (data set identifier PXD006631) and construction of protein interaction networks, we elucidate exactly how the genotype and phenotype are related at the molecular level. Our multi-omics approach points to the rewiring of numerous metabolic pathways affected by genomic and proteomic level changes, from energy-producing and lipid pathways to differential regulation of transposons and proteins invol

SUBMITTER: Sostaric N 

PROVIDER: S-EPMC8353626 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature